Effects of mechanically separated dairy cow slurry on grazing performance

No abstract available

A novel locus for autosomal recessive primary microcephaly (MCPH6) maps to 13q12.2

Key points: • Autosomal recessive primary microcephaly (MCPH) is a genetic disorder in which an affected subject is born with a head circumference >3 SD below the expected mean and is mentally retarded. • We report a novel locus (MCPH6) mapped to chromosome 13q12.2 in a Brazilian family. • The minimal critical region spans 6 Mb between markers AL139378GT17 and D13S1244 with a maximum two point lod score of 6.25

Healthcare risk waste and waste legislation in South Africa

Published ArticleHealthcare risk waste is highly regulated in several countries by well-developed legislative frameworks; however, there is a lack of development and adherence to directives and laws in developing countries such as South Africa. Although legislation is in place, it does not always address medical waste in detail to assist with issues such as segregation, categorisation, collection, transport, treatment and final disposal practices. Incineration is still the most common means of treatment, which has shifted the focus of the Department of Environmental Affairs, the department responsible for overseeing waste disposal, to air quality monitoring. The objective of this paper is to highlight issues related to HCRW management, and to suggest a way forward, rather than to provide an in-depth analysis of the problem

Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36

Kufor-Rakeb syndrome is an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration. The onset is in the teenage years with clinical features of Parkinson’s disease plus spasticity, supranuclear upgaze paresis, and dementia. Brain scans show atrophy of the globus pallidus and pyramids and, later, widespread cerebral atrophy. We report linkage in Kufor- Rakeb syndrome to a 9 cM region of chromosome 1p36 delineated by the markers D1S436 and D1S2843, with a maximum multipoint lod score of 3.6. (J Med Genet 2001;38:680–682

Rapid thermal rejuvenation of high-crystallinity magma linked to porphyry copper deposit formation; evidence from the Koloula Porphyry Prospect, Solomon Islands

Magmas containing the components needed to form porphyry copper deposits are relatively common within arcs, yet mineralising events are uncommon within the long-lived magmatic systems that host them. Understanding what causes the transition from barren to productive intrusions is critical to the development of conceptual deposit models. We have constrained the tempo of pre- and syn-mineralisation magmatic events in relationship to the thermal evolution of the plutonic body that underlies one of the world's youngest exposed plutonic–porphyry systems, the Inamumu Zoned Pluton, Koloula Porphyry Prospect, Solomon Islands. High precision ID-TIMS U–Pb dates of texturally and chemically characterised zircons indicate pluton emplacement over 50% crystals) state, past the point of rheological lock-up. We estimate that thermal rejuvenation of the deeper high-crystallinity magma and generation of a mobile melt fraction may have occurred ≤10 kyr before its transport and emplacement within the porphyry environment. The underlying pluton likely cooled and returned to high-crystallinity states prior to subsequent remobilisation-emplacement events. Titanium-in-zircon geothermometry and whole-rock geochemistry suggest pre-mineralisation intrusions were remobilised by mixing of a silicic magma with a high-temperature, less-evolved melt. In contrast, syn-mineralisation melts were most likely remobilised by the percolation of hot volatiles exsolved from contemporaneous less-evolved intrusions cooling beneath the crystalline silicic magma. The evidence for the rapid thermal rejuvenation and long term storage of highly crystalline silicic magmas is consistent with previous studies that indicate two components of exsolved volatiles contribute to ore forming fluids. We conclude that the liberation of crystal-rich porphyry copper deposit forming magmas, and the addition of the chemical components required for ore formation, are intrinsically linked to the volatiles released during the recharge of less-evolved melt into a highly crystalline silicic magma

Autosomal recessive primary microcephaly: an analysis of locus heterogeneity and phenotypic variation

BACKGROUND AND OBJECTIVES: Locus heterogeneity is well established in autosomal recessive primary microcephaly (MCPH) and to date five loci have been mapped. However, the relative contributions of these loci have not been assessed and genotype-phenotype correlations have not been investigated. DESIGN: A study population of 56 consanguineous families resident in or originating from northern Pakistan was ascertained and assessed by the authors. A panel of microsatellite markers spanning each of the MCPH loci was designed, against which the families were genotyped. RESULTS: The head circumference of the 131 affected subjects ranged from 4 to 14 SD below the mean, but there was little intrafamilial variation among affecteds (± 1 SD). MCPH5 was the most prevalent, with 24/56 families consistent with linkage; 2/56 families were compatible with linkage to MCPH1, 10/56 to MCPH2, 2/56 to MCPH3, none to MCPH4, and 18/56 did not segregate with any of the loci. CONCLUSIONS: MCPH5 is the most common locus in this population. On clinical grounds alone, the phenotype of families linked to each MCPH locus could not be distinguished. We have also shown that further MCPH loci await discovery with a number of families as yet unlinked

High power femtosecond source based on passively mode-locked 1055nm VECSEL and Yb-fibre power amplifier

We report 5 ns pulses at 160 W average power and 910 repetition rate from a passively mode-locked VECSEL source seeding an Yb-doped fibre power amplifier. The amplified pulses were compressed to 291 fs duration

A spectral-timing model for ULXs in the supercritical regime

Ultraluminous X-ray sources (ULXs) with luminosities lying between ∼3 × 1039 and 2 × 1040 erg s−1 represent a contentious sample of objects as their brightness, together with a lack of unambiguous mass estimates for the vast majority of the central objects, leads to a degenerate scenario where the accretor could be a stellar remnant (black hole or neutron star) or intermediate-mass black hole (IMBH). Recent, high-quality observations imply that the presence of IMBHs in the majority of these objects is unlikely unless the accretion flow somehow deviates strongly from expectation based on objects with known masses. On the other hand, physically motivated models for supercritical inflows can re-create the observed X-ray spectra and their evolution, although have been lacking a robust explanation for their variability properties. In this paper, we include the effect of a partially inhomogeneous wind that imprints variability on to the X-ray emission via two distinct methods. The model is heavily dependent on both inclination to the line of sight and mass accretion rate, resulting in a series of qualitative and semiquantitative predictions. We study the time-averaged spectra and variability of a sample of well-observed ULXs, finding that the source behaviours can be explained by our model in both individual cases as well as across the entire sample, specifically in the trend of hardness-variability power. We present the covariance spectra for these sources for the first time, which shed light on the correlated variability and issues associated with modelling broad ULX spectra

Researching trust in the police and trust in justice: a UK perspective

This paper describes the immediate and more distant origins of a programme of comparative research that is examining cross-national variations in public trust in justice and in the police. The programme is built around a module of the fifth European Social Survey, and evolved from a study funded by the European Commission. The paper describes the conceptual framework within which we are operating – developed in large measure from theories of procedural justice. It reviews some of the methodological issues raised by the use of sample surveys to research issues of public trust in the police, public perceptions of institutional legitimacy and compliance with the law. Finally it gives a flavour of some of the early findings emerging from the programme

An Investigation Into The Role Of The Quantity Surveyor In The Value Management Workshop Process

Purpose: This research investigates the value management workshop process and specifically identifies the roles and responsibilities of the Quantity Surveyor within this. Information accrued is then used to develop a novel template value management workshop that provides a platform for educating future Quantity Surveying and other construction professionals. Research Approach: This research adopts a mixed philosophical epistemological design that utilises interpretivism with elements of postpositivism. Specifically, a cross sectional study of extant literature informs the development of a structured questionnaire that is posed to focus group participants (consisting of experienced industrial practitioners) to secure qualitative feedback and validate the template. Findings: Research findings reveal that the roles and responsibilities of the Quantity Surveyor in the value management workshop process has hitherto received scant academic attention. Additionally, literature has revealed that available information on workshop content is limited leading to ineffective studies. There has also been a miscommunication among construction practitioners in relation to the Quantity Surveyor’s role in the workshop process. Following extensive research, a novel template has been created which identifies the content of each workshop session alongside the roles and responsibilities of the Quantity Surveyor (and other construction professionals) which can be used for educational purposes. Originality: Literature revealed that scant academic and professional governing body(ies) attention has been paid to the education and training of future generations of Quantity Surveyors involved in value management. Specifically, there is limited applied case study evidence to investigate this phenomena and hence, the workshop curricular presented advances knowledge in this respect and provides a practical template solution